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Welcome from ec2-18-190-217-134.us-east-2.compute.amazonaws.com.
This is version 1.20 of the Surface Entropy Reduction prediction (SERp) server from January 2007. This exploratory tool aims to aid identification of sites that are most suitable for mutation designed to enhance crystallizability by a Surface Entropy Reduction approach.

This server is no longer supported and no longer requires authentication.
Job submissions are not available at the moment.

More Info: introduction page, publication reference.



Sequences producing significant alignments:

Sequences found by the PSI-BLAST search in order of decreasing identity. Overall scoring statistics for each aligned sequence are shown. For each proposed cluster, changes in the aligned sequence are highlited.

Click the [+] link to see the complete alignment and further details.

Note: sequences with >99% identity are excluded from contributing to the analysis score but are shown below.

Sequence alignment legend:
. -- no change
- -- gap
K -- other high entropy residue
A -- mutated to target residue
  Cluster shading legend:
X -- residue witin proposed patch
K -- residue proposed for mutation
D -- other mutable high entropy residue
A -- low entropy target residue
Ext. Reference & Link
Annotation		 e Value  Bits  Identity  Cluster #1:
134-137
KEPA		 Cluster #2:
314-320
AAKEAIA		 Cluster #3:
66-74
EAALEYKPQ
[+] 75909717: ref: YP_324013.1 1.82·10-144 516.2 100% .... ....... .........
  hypothetical protein Ava_3511 [Anabaena variabilis ATCC...
[+] 186686608: ref: YP_001869804.1 5.01·10-140 501.6 87.6% ...P ..E.S.. A...Q...E
  hypothetical protein Npun_R6603 [Nostoc punctiforme PCC...