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This is version 1.20 of the Surface Entropy Reduction prediction (SERp) server from January 2007. This exploratory tool aims to aid identification of sites that are most suitable for mutation designed to enhance crystallizability by a Surface Entropy Reduction approach. More Info: introduction page, publication reference.

Please send bug reports, questions and feedback to adminstrator <>. To submit multiple sequences in FASTA format, use the Batch Submission page.

The meta search attempts to detect other potential crystallization failure modes and identify sequence regions that may be important for function.

PDB / Surface Accessibility » PDB website | » DSSP website
List homologous structures (PDBs) and performs a DSSP analysis for solvent accessibility.

Indentity cutoff:

Blocks are multiply-aligned, ungapped segments corresponding to the most highly conserved regions of proteins. This search identifies highly conserved motifs such as metal binding sites; addition of the corresponding metal may be required for crystallization.

E-value cutoff: