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Welcome from ec2-3-17-186-218.us-east-2.compute.amazonaws.com.
This is version 1.20 of the Surface Entropy Reduction prediction (SERp) server from January 2007. This exploratory tool aims to aid identification of sites that are most suitable for mutation designed to enhance crystallizability by a Surface Entropy Reduction approach.

This server is no longer supported and no longer requires authentication.
Job submissions are not available at the moment.

More Info: introduction page, publication reference.



Sequences producing significant alignments:

Sequences found by the PSI-BLAST search in order of decreasing identity. Overall scoring statistics for each aligned sequence are shown. For each proposed cluster, changes in the aligned sequence are highlited.

Click the [+] link to see the complete alignment and further details.

Note: sequences with >99% identity are excluded from contributing to the analysis score but are shown below.

Sequence alignment legend:
. -- no change
- -- gap
K -- other high entropy residue
A -- mutated to target residue
  Cluster shading legend:
X -- residue witin proposed patch
K -- residue proposed for mutation
D -- other mutable high entropy residue
A -- low entropy target residue
Ext. Reference & Link
Annotation		 e Value  Bits  Identity  Cluster #1:
62-64
QKE		 Cluster #2:
27-34
KAKIQDKE		 Cluster #3:
48-51
KQLE
[+] 5523975: gb: AAD44040.1 1.02·10-38 162.9 100% ... ........ ....
  polyprotein [Bovine viral diarrhea virus 2]
[+] 114577583: ref: XP_001147989.1 1.02·10-38 162.9 100% ... ........ ....
  PREDICTED: similar to RPS27A protein [Pan troglodytes]