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The weight used in the evolutionary conservation analysis. This analysis locates conserved residues and residues that in other homologs exist are already changed to a target residue. Conserved residues provide a negative contribution to the overall score and hence are disfavored as site for mutation. Residues that in other homologs already exist as one of the target residues have a positive contribution and are hence preferred for mutation.

The overall score at each position in the provided sequence is composed of three scores: the secondary structure prediction score, the side chain entropy score and the BLAST search score.

By default the weight for the BLAST search is 1 and equivalent to the secondary structure prediction model weight, while the side entropy weight is 0.5 (since the cluster pattern search provides additional emphasis for the side entropies).

These weight may be adjusted if one wished to give more emphasis on one of the three models described above.