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Minimum number of mutations to propose for a cluster. One residue change may be sufficient to enhance crystallizability hence the default for this parameter is 1. Typically two or three mutations are required to change the entropy sufficiently. However, as the introduction of each mutation reduces solubility and can also affect the fold or structure of the protein, clusters with the lower number of required mutations are preferred. This is NOT a strict limit. If possible, clusters with as few as one mutations may be proposed.